Parkinson's Disease : Molecular Mechanisms Underlying Pathology (2017, E-book) TXT read online ebook
9780128038055 English 0128038055 Parkinson's Disease: Molecular Mechanisms Underlying Pathology explores the molecular pathways at the basis of the cellular defects connected to Parkinson's disease, the second most common neurodegenerative disease, and the most common movement disorder. This book presents the latest research on the pathways and mechanisms that have been discovered to play a role in Parkinson pathology. This focus on mechanisms rather than individual genes allows the contributors to elaborate on overlapping and joint functions of different Parkinson-causative genes. Users will find descriptions of model systems that present parallels (and differences) between discoveries in different species, demonstrating the importance of multidisciplinary research that spans a broad array of technologies and model organisms. Written from both a cross-methodology and cross-species perspective, the book provides readers with the current state of knowledge on the molecular biology of Parkinson's. Written by experts in the field that focus on pathways and mechanisms implicated in Parkinson's pathology rather than clinical presentation Draws parallels between multidisciplinary discoveries in different model organisms using an array of technologies Provides a cross-methodology and cross-species approach to understanding the molecular biology of Parkinson's disease Includes approximately 25 color Illustrations and diagrams to explain concepts and models Focuses on key pathways and mechanisms (as opposed to model organism or gene) to provide a multidisciplinary approach to Parkinson's disease, Parkinson's disease is the second most common neurodegenerative disease and the most common movement disorder. Symptomatic treatments exist, alleviating some but not all disease features with limited effect. Similar to other neurodegenerative diseases, most Parkinson cases are of sporadic origin but about 10% are familial, with approximately a dozen causative genes discovered to date. These genes and corresponding pathways have provided a molecular handle to study the mechanisms of Parkinson's and the hope is that by understanding the pathological mechanisms of these familial forms of the disease, researchers will also gain insight into the sporadic cases of the disease. Parkinson's Disease: Molecular Mechanisms Underlying Pathology explores the molecular pathways at the basis of the cellular defects connected to Parkinson's disease, and highlights possible treatment options. This book focuses on pathways and mechanisms that have been discovered to play a role in Parkinson pathology. This focus on mechanisms rather than individual genes allows the contributors to elaborate on overlapping and joint functions of different Parkinson-causative genes. The book describes model systems used to study Parkinson's and draws parallels (and differences) between discoveries in different species, demonstrating the importance of multidisciplinary research that spans a broad array of technologies and model organisms. Written from both a cross-methodology and a cross-species perspective, this book provides the audience with the current state of knowledge on the molecular biology of Parkinson's disease. A solid understanding of the cellular biology and molecular pathology underlying this multifaceted disease is of importance if the research community hopes to arrive at an understanding of the origins of this disease and develop effective therapeutic strategies. Written by experts in the field and starting from experimental results, focusing on pathways and mechanisms implicated in Parkinson's pathology rather than clinical presentation Draws parallels between multidisciplinary discoveries in different model organisms using an array of technologies Provides a cross-methodology and cross-species approach to understanding the molecular biology of Parkinson's disease Includes approximately 25 colour Illustrations and diagrams to explain concepts and models Focuses on key pathways and mechanisms (as opposed to model organism or gene) as to provide a multidisciplinary inroad to Parkinson's disease Chapters include references (key articles, books, protocols) for additional detailed study
9780128038055 English 0128038055 Parkinson's Disease: Molecular Mechanisms Underlying Pathology explores the molecular pathways at the basis of the cellular defects connected to Parkinson's disease, the second most common neurodegenerative disease, and the most common movement disorder. This book presents the latest research on the pathways and mechanisms that have been discovered to play a role in Parkinson pathology. This focus on mechanisms rather than individual genes allows the contributors to elaborate on overlapping and joint functions of different Parkinson-causative genes. Users will find descriptions of model systems that present parallels (and differences) between discoveries in different species, demonstrating the importance of multidisciplinary research that spans a broad array of technologies and model organisms. Written from both a cross-methodology and cross-species perspective, the book provides readers with the current state of knowledge on the molecular biology of Parkinson's. Written by experts in the field that focus on pathways and mechanisms implicated in Parkinson's pathology rather than clinical presentation Draws parallels between multidisciplinary discoveries in different model organisms using an array of technologies Provides a cross-methodology and cross-species approach to understanding the molecular biology of Parkinson's disease Includes approximately 25 color Illustrations and diagrams to explain concepts and models Focuses on key pathways and mechanisms (as opposed to model organism or gene) to provide a multidisciplinary approach to Parkinson's disease, Parkinson's disease is the second most common neurodegenerative disease and the most common movement disorder. Symptomatic treatments exist, alleviating some but not all disease features with limited effect. Similar to other neurodegenerative diseases, most Parkinson cases are of sporadic origin but about 10% are familial, with approximately a dozen causative genes discovered to date. These genes and corresponding pathways have provided a molecular handle to study the mechanisms of Parkinson's and the hope is that by understanding the pathological mechanisms of these familial forms of the disease, researchers will also gain insight into the sporadic cases of the disease. Parkinson's Disease: Molecular Mechanisms Underlying Pathology explores the molecular pathways at the basis of the cellular defects connected to Parkinson's disease, and highlights possible treatment options. This book focuses on pathways and mechanisms that have been discovered to play a role in Parkinson pathology. This focus on mechanisms rather than individual genes allows the contributors to elaborate on overlapping and joint functions of different Parkinson-causative genes. The book describes model systems used to study Parkinson's and draws parallels (and differences) between discoveries in different species, demonstrating the importance of multidisciplinary research that spans a broad array of technologies and model organisms. Written from both a cross-methodology and a cross-species perspective, this book provides the audience with the current state of knowledge on the molecular biology of Parkinson's disease. A solid understanding of the cellular biology and molecular pathology underlying this multifaceted disease is of importance if the research community hopes to arrive at an understanding of the origins of this disease and develop effective therapeutic strategies. Written by experts in the field and starting from experimental results, focusing on pathways and mechanisms implicated in Parkinson's pathology rather than clinical presentation Draws parallels between multidisciplinary discoveries in different model organisms using an array of technologies Provides a cross-methodology and cross-species approach to understanding the molecular biology of Parkinson's disease Includes approximately 25 colour Illustrations and diagrams to explain concepts and models Focuses on key pathways and mechanisms (as opposed to model organism or gene) as to provide a multidisciplinary inroad to Parkinson's disease Chapters include references (key articles, books, protocols) for additional detailed study